Effects of Roflumilast on Airway Hyperresponsiveness (AHR)
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چکیده
منابع مشابه
Alcohol reduces airway hyperresponsiveness (AHR) and allergic airway inflammation in mice.
There is very limited knowledge about the effects of alcohol on airway hyperresponsiveness and inflammation in asthma. Historical accounts of alcohol administration to patients with breathing problems suggest that alcohol may have bronchodilating properties. We hypothesized that alcohol exposure will alter airway hyperresponsiveness (AHR) and pulmonary inflammation in a mouse model of allergic ...
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Ambroxol is used in COPD and asthma to increase mucociliary clearance and regulate surfactant levels, perhaps through anti-oxidant and anti-inflammatory activities. To determine the role and effect of ambroxol in an experimental model of asthma, BALB/c mice were sensitized to ovalbumin (OVA) followed by 3 days of challenge. Airway hyperresponsiveness (AHR), lung cell composition and histology, ...
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15 صفحه اولVirus-induced Airway Hyperresponsiveness
Intratracheal inoculation of parainfluenza type 3 virus to guinea pigs induces a marked increase in airway responsiveness in vivo and in vitro. In spontaneously breathing anesthetized guinea pigs inhalation of an aerosol containing the nitric oxide (NO) precursor L-argimine (2.0 mM) completely prevented the virus-induced airway hyperresponsiveness to histamine. In addition, perfusion of L-argin...
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I read with much interest the review by MEURS et al. [1], in which they examined the relative merits of several animal models of airway hyperresponsiveness (AHR), and the insights these models provide into the mechanisms of airway physiology and pathophysiology. The study appropriately focused on the role of nitric oxide (NO) as a transmitter of the inhibitory (i.e. relaxant) nonadrenergic, non...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2016
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2015.12.1273